山东第一医科大学高层次拔尖人才，医学人工智能与大数据学院教授、核酸大数据与智慧医学实验室PI;主要从事多组学数据的生物信息学研究、癌症等重大疾病的复杂调控机制研究、基于医疗大数据的临床决策系统研究等方向，发表SCI总引用次数近千次。其中研究长非编码RNA的代表性文章发表在Nucleic Acids Research杂志上，SCI它引超过700次。目前共主持国家自然科学基金两项，国家重点研发计划课题一项，省级创新团队一项。

2008年开始在国内从事转录组学为主的生物信息学研究，随着测序技术的快速发展于2013年前后进行多生命组学相关的科学研究，2016年开始将研究方向转为基于多组学与医疗大数据的临床科学问题研究。

l 转录组学为主的生物信息学研究

l 癌症等重大疾病的多生命组学复杂调控网络研究

l 基于医疗大数据与人工智能算法的临床决策系统研究

l 应用级别的组学大数据平台研发

代表性论文 (*第一或通讯作者)

[1] Sun, L.*, Luo, H., Bu, D., Zhao, G., Yu, K., Zhang, C., ... & Zhao, Y. (2013). Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts. Nucleic acids research, 41(17), e166-e166.(SCI, IF:11.147)

● 他引次数：700+次，生物学、基因组学高被引论文。

● 生物学中科院一区，TOP期刊。

[2] Guo, J. C., Fang, S. S., Wu, Y., Zhang, J. H., Chen, Y., Liu, J., ... & Sun, L.* (2019). CNIT: a fast and accurate web tool for identifying protein-coding and long non-coding transcripts based on intrinsic sequence composition. Nucleic acids research, 47(W1), W516-W522.(SCI, IF: 16.971)

● 他引次数：26次。

● 生物学中科院一区，TOP期刊。

[3] Sun, L.*, Luo, H., Liao, Q., Bu, D., Zhao, G., Liu, C., ... & Zhao, Y. (2013). Systematic study of human long intergenic non-coding RNAs and their impact on cancer. Science China Life Sciences, 56(4), 324-334.1.(SCI, IF:4.611)

● 他引次数：32次.

● 生物学中科院一区，TOP期刊。

[4] Su X, Yu Z, Zhang Y, Chen J, Wei L, Sun L. Construction and Analysis of the Dysregulated ceRNA Network and Identification of Risk Long Noncoding RNAs in Breast Cancer. Front Genet. 2021 Jun 4;12:664393. (SCI, IF:4.599)

[5] Fan L, Li B, Li Z, Sun L. Identification of Autophagy Related circRNA-miRNA-mRNA-Subtypes Network With Radiotherapy Responses and Tumor Immune Microenvironment in Non-small Cell Lung Cancer. Front Genet. 2021 Sep 9;12:730003. (SCI, IF:4.599)

[6] Hong, S., Hu, S., Kang, Z., Liu, Z., Yang, W., Zhang, Y., Sun, L.* & Chen, L*. (2020). Identification of functional lncRNAs based on competing endogenous RNA network in osteoblast differentiation. Journal of Cellular Physiology, 235(3), 2232-2244.(SCI, IF:5.6)

[7] Fang, S. S., Guo, J. C., Zhang, J. H., Liu, J. N., Hong, S., Yu, B., Sun, L.* & Zhao, Y.* (2020). A P53‐related microRNA model for predicting the prognosis of hepatocellular carcinoma patients. Journal of Cellular Physiology , 235 (4), 3569-3578.(SCI, IF:5.6)

[8] Jiang, H., Zhao, L., Chen, Y., & Sun, L.* (2020). A four‐long noncoding RNA signature predicts survival of hepatocellular carcinoma patients. Journal of Clinical Laboratory Analysis , e23377.1.(SCI, IF:1.54)

[9] Song, X.*, Sun, L.*, Luo, H., Ma, Q., Zhao, Y., & Pei, D. (2016). Genome-wide identification and characterization of long non-coding RNAs from mulberry (Morus notabilis) RNA-seq Data. Genes, 7(3), 11.1.(SCI, IF:4.096)

书章

1. Liao Q., Bu D., Sun L., Luo H., Zhao Y. (2017) Identification and Functional Annotation of LncRNAs in Human Disease. In: Xu D., Wang M., Zhou F., Cai Y. (eds) Health Informatics Data Analysis. Health Information Science. Springer, Cham. https://doi.org/10.1007/978-3-319-44981-4_3

专利