山东第一医科大学高层次拔尖人才，医学人工智能与大数据学院教授、转化基因组学课题组长，山东省泰山学者青年专家，国家青年人才项目评审。博士毕业于中国科学院上海生命科学学院。曾任职于美国南加州大学、费城儿童医院。目前主要从事人类遗传疾病和生物信息方向的研究，代表文章以第一作者或通讯作者发表在Cell Research, Nature Communications(三篇), The Innovation, Journal of the National Cancer Institute (两篇) 和 Journal of Allergy and Clinical Immunology (三篇)。
代表性论文
(1) Ziang Meng#, Yingchao Song#, Yue Jiang, Xianjin Wang, Yang Zou, Xingyuan Li, Hakon Hakonarson*, Xiao Chang*; Transformer-based deep learning enhances discovery in migraine GWAS; Nature Communications, 2025. (期刊论文；IF=17.2)
(2) Lili Zhi#, Qiwen Zheng#, Yue Jiang#, Lu Yu, Linzehao Li, Yingchao Song, Bichen Peng, Chumeng Zhang, Hengxuan Jiang, Ren Li, Frank Mentch, Joseph Glessner, Peilin Jia, Hua Tang*, Hakon Hakonarson*, Xiao Chang*; Multi-trait genetic analysis of asthma and eosinophils uncovers pleiotropic loci in East Asians; Nature Communications, 2025, 16(1): 5081. (期刊论文；IF=17.2)
(3) Yingchao Song, Linzehao Li, Yue Jiang, Bichen Peng, Hengxuan Jiang, Zhen Chao, Xiao Chang*; Multitrait Genetic Analysis Identifies Novel Pleiotropic Loci for Depression and Schizophrenia in East Asians; Schizophrenia Bulletin, 2025, 51(3): 684-695. (期刊论文；IF=6.0)
(4) Huanxin Ding, Yue Jiang, Qing Sun, Yingchao Song, Shuohui Dong, Qian Xu, Linzehao Li, Chuxuan Liu, Bingjun Li, Hengxuan Jiang, Bichen Peng, Shi Peng, Chumeng Zhang, Jiankang Zhu, Mingwei Zhong, Guangyong Zhang*, Xiao Chang*; Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders; Communications Biology, 2025, 8(1): 47. (期刊论文；IF=5.8)
(5) Xiao Chang*, Huiqi Qu, Yichuan Liu, Joseph Glessner, Hakon Hakonarson*; A Protective Role of Low Polygenic Risk Score in Healthy Individuals Carrying Attention-Deficit/Hyperactivity Disorder–Associated Copy Number Variations; Biological Psychiatry, 2024, 95(9): 881-887. (期刊论文；IF=10.4)
(6) Xiao Chang*, Hui-Qi Qu, Yichuan Liu, Joseph T. Glessner, Hakon Hakonarson*; Mitochondrial DNA Haplogroup K Is Protective Against Autism Spectrum Disorder Risk in Populations of European Ancestry; Journal of the American Academy of Child and Adolescent Psychiatry, 2024, 63(8): 835-844. (期刊论文；IF=10.6)
(7) Xiao Chang*, Michael March, Frank Mentch, Huiqi Qu, Yichuan Liu, Joseph Glessner, Patrick Sleiman, Hakon Hakonarson*; Genetic architecture of asthma in African American Patients; Journal of Allergy and Clinical Immunology, 2022 Sep 8. (期刊论文；IF=10.5)
(8) Xiao Chang, Yichuan Liu, Joseph Glessner, Cuiping Hou, Huiqi Qu, Kenny Nguyen, Patrick Sleiman, Lobin Lee, Sharon J Diskin, John M Maris, Hakon Hakonarson*; Identification of Mitochondrial DNA Variants Associated With Risk of Neuroblastoma, JNCI: Journal of the National Cancer Institute, 2022, 114(6): 910-913. (期刊论文；IF=9.4)
(9) Xiao Chang, Michael March, Frank Mentch, Kenny Nguyen, Joseph Glessner, Huiqi Qu, Yichuan Liu, Glen Furuta, Seema Aceves, Nirmala Gonsalves, Kari Nadeau, Antonella Cianferoni, Jonathan Spergel, Patrick Sleiman, Hakon Hakonarson*; A genome-wide association meta-analysis identifies new eosinophilic esophagitis loci, Journal of Allergy and Clinical Immunology, 2022, 149(3): 988-998. (期刊论文； IF=10.5)
(10) Xiao Chang; Marina Bakay; Yichuan Liu; Joseph Glessner; Komal S Rathi; Cuiping Hou; Huiqi Qu; Zalman Vaksman; Kenny Nguyen; Patrick M A Sleiman; Sharon J Diskin; John M Maris; Hakon Hakonarson*; Mitochondrial DNA haplogroups and susceptibility to neuroblastoma, JNCI: Journal of the National Cancer Institute, 2020, 112(12): 1259-1266. (期刊论文；IF=9.4)
(11) Stanislaw J. Gabryszewski#; Xiao Chang#; Jesse W. Dudley; Frank Mentch; Michael March; John H. Holmes; Jason Moore; Robert W. Grundmeier; Hakon Hakonarson; David A. Hill*; Unsupervised modeling and genome-wide association identify novel features of allergic march trajectories, Journal of Allergy and Clinical Immunology, 2021, 147(2): 677-685. (期刊论文；IF=10.5)
(12) Xiao Chang#, Yun Li#, Kenny Nguyen, Huiqi Qu, Yichuan Liu, Joseph Glessner, Patrick MA Sleiman, Hakon Hakonarson*; Genetic correlations between COVID-19 and a variety of traits and diseases, The Innovation, 2021, 2(2): 100112. (期刊论文；IF=40.2)
(13) Xiao Chang; Yan Zhao; Cuiping Hou; Joseph Glessner; Lee McDaniel; Maura A. Diamond; Kelly Thomas; Jin Li; Zhi Wei; Yichuan Liu; Yiran Guo; Frank D. Mentch; Haijun Qiu; Cecilia Kim; Perry Evans; Zalman Vaksman; Sharon J. Diskin; Edward F. Attiyeh; Patrick Sleiman; John M. Maris*; Hakon Hakonarson*; Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk, Nature Communications, 2017, 8(1): 1-7. (期刊论文；IF=16.6)
(14) Yi Zhong#; Xiao Chang#; Xing-Jun Cao#; Yan Zhang; Huajun Zheng; Yongzhang Zhu; Chengsong Cai; Zelin Cui; Yunyi Zhang; Yuan-Yuan Li; Xiu-Gao Jiang; Guo-Ping Zhao; Shengyue Wang*; Yixue Li*; Rong Zeng*; Xuan Li*; Xiao-Kui Guo*; Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601, Cell Research, 2011, 21(8): 1210-1229. (期刊论文；IF=36.6)
科研项目
1. 国家自然科学基金面上项目，32270661，线粒体基因组变异影响神经母细胞瘤发病风险的遗传机制研究，2023-01至2026-12，54万元，主持
2. 山东省优秀青年科学基金项目（海外），生物信息学在儿童实体肿瘤遗传机制研究中的应用，60万元，主持
专利
1. 常啸，Genet基因调控网络分析系统，2016.06.06，中国，2016SR200934
2. Hakon Hakonarson，Patrick Sleiman，Xiao Chang，Schizophrenia-associated genetic loci identified in genome-wide association studies and methods of use thereof, 2018.10.16, 美国，14853987
